: The purpose of this study is to estimate the determinant factors of the profitabilityon Indonesian banking industry. Factors used are bank's internal factors and external factors.Internal factors include the variables inherent in the bank, while external factors includeindustry-specific variables and macroeconomic variables. The data used is the entire bankingin the period 2004-2011. The analytical method used is panel data regression model withpooled least squares method, the fixed effect method and random effect method. The resultsshowed that determinant factors of banking profitability in Indonesian can be explained byfixed effect model, and variable capital, loans, bank size, market structure, and inflationaffect the profitability of banks in Indonesia, but the growth of per capita income has noeffect.